NEPHELE’s hybrid electronic-optical network architecture scales linearly with the number of datacenter hosts and consolidates compute and storage networks over a single, Ethernet optical TDMA network. Low latency, hardware-level dynamic re-configurability and quasi-deterministic QoS are supported in view of disaggregated datacenter deployment scenarios. A fully functional control plane overlay is being developed, comprising a Software-Defined Networking (SDN) controller along with its interfaces. The southbound interface abstracts physical layer infrastructure and allows dynamic hardware-level network reconfigurability. The northbound interface links the SDN controller with the application requirements through an Application Programming Interface. NEPHELE’s innovative control plane enables Application Defined Networking and merges hardware and software virtualization over the hybrid optical infrastructure. It also integrates SDN modules and functions for inter-datacenter connectivity, enabling dynamic bandwidth allocation based on the needs of migrating VMs, as well as on existing Service Level Agreements for transparent networking among telecom and datacenter operators’ domains.